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The presence of antibodies against the AD 2 epitope of cytomegalovirus glycoprotein B is associated with acute rejection after renal transplantation
Author(s) -
Ishibashi Kei,
Tokumoto Tadahiko,
Shirakawa Hiroki,
Oguro Toshiki,
Yanagida Tomohiko,
Takahashi Norio,
Nomiya Masanori,
Haga Nobuhiro,
Aikawa Ken,
Tanabe Kazunari,
Inoue Naoki,
Kojima Yoshiyuki,
Suzutani Tatsuo
Publication year - 2014
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12112
Subject(s) - cytomegalovirus , antibody , transplantation , immunology , epitope , betaherpesvirinae , glycoprotein , kidney transplantation , virology , human cytomegalovirus , medicine , biology , herpesviridae , virus , viral disease , microbiology and biotechnology
ABSTRACT The aim of this study was to evaluate the association between antibodies against cytomegalovirus (CMV) glycoprotein B (gB) and acute rejection after transplantation. Seventy‐seven consecutive renal transplant recipients in a D + /R+ setting were studied. Biopsy‐proven rejection occurred in 35% of the recipients. Among these recipients, 85% had antibodies against CMV gB. The rate of acute rejection was significantly higher in recipients with antibodies against gB than in those without them. Antibodies against gB can be a useful predictor of acute rejection in renal transplant recipients in a D + /R+ setting.