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Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle
Author(s) -
Suzuki Saori,
Konnai Satoru,
Okagawa Tomohiro,
Ikebuchi Ryoyo,
Shirai Tatsuya,
Sunden Yuji,
Mingala Claro N.,
Murata Shiro,
Ohashi Kazuhiko
Publication year - 2013
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12073
Subject(s) - bovine leukemia virus , biology , foxp3 , titer , virology , virus , flow cytometry , microbiology and biotechnology , immunology , immune system
In the present study, we monitored Foxp3 + T cells in bovine leukemia virus (BLV)‐infected cattle. By flow cytometric analysis, the proportion of Foxp3 + CD4 + cells from persistent lymphocytotic cattle was significantly increased compared to control and AL cattle. Interestingly, the proportion of Foxp3 + CD4 + cells correlated positively with the increased number of lymphocytes, virus titer and virus load, whereas it inversely correlated with IFN‐γ mRNA expression, suggesting that Foxp3 + CD4 + T cells in cattle have a potentially immunosuppressive function. Further studies are necessary to elucidate the detailed mechanism behind the increased Treg during BLV infection.