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Cephalosporin resistant Escherichia coli from cancer patients in Cairo, Egypt
Author(s) -
Abdelaziz Mohammed O.,
Bonura Celestino,
Aleo Aurora,
Fasciana Teresa,
Calà Cinzia,
Mammina Caterina
Publication year - 2013
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12046
Subject(s) - cephalosporin , escherichia coli , biology , microbiology and biotechnology , phylogenetic tree , multiple drug resistance , cancer , gene , genetics , antibiotics
Cephalosporin‐resistant Escherichia coli has been increasingly reported worldwide. In this study, 32 cephalosporin resistant E. coli isolates identified from cancer patients in Cairo, Egypt in 2009–2010 were analyzed. Twenty‐three were of phylogenetic group D, seven A and one each B1 and B2. By rep‐PCR 15 phylogroup D isolates were grouped in four clusters, one with sequence type (ST) 405 and three ST68. Seventeen isolates showed single patterns. bla CTX‐M‐15 and aac ( 6 ') ‐Ib‐cr were the most common resistance determinants. bla OXA‐48 and bla VIM were also detected. Multidrug resistant E. coli seriously affects healthcare, especially in immunocompromised hosts, such as cancer patients.