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Molecular epidemiology of Coxsackievirus A16 strains isolated from children in Yamagata, Japan between 1988 and 2011
Author(s) -
Mizuta Katsumi,
Abiko Chieko,
Aoki Yoko,
Ikeda Tatsuya,
Matsuzaki Yoko,
Hongo Seiji,
Itagaki Tsutomu,
Katsushima Noriko,
Ohmi Akira,
Nishimura Hidekazu,
Ahiko Tadayuki
Publication year - 2013
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12041
Subject(s) - biology , virology , epidemiology , molecular epidemiology , coxsackievirus , genetics , microbiology and biotechnology , enterovirus , virus , gene , genotype , medicine
To clarify the longitudinal molecular epidemiology of coxsackievirus A16, phylogenetic analysis based on the VP1 region of 220 isolates in Yamagata, Japan was performed. The resultant phylogenetic tree indicates that the Yamagata isolates and reference strains can be readily genotyped into three genogroups, and 0, 12 and 208 isolates belonged to the first, second, and third genogroups, respectively. The first genogroup includes only the prototype strain, the second strains that had disappeared by the end of the 20th century and the third comprises those that have been circulating since then in local communities, such as Yamagata.