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Pyriproxyfen enhances the immunoglobulin G immune response in mice
Author(s) -
Sharmin Tanjina,
Satho Tomomitsu,
Irie Keiichi,
Watanabe Mineo,
Hosokawa Masato,
Hiramatsu Yukihiro,
Talukder Parimal,
Okuno Takahiro,
Tsuruda Shodai,
Uyeda Saori,
Fukmits Yuki,
Tamura Yukie,
Nakashima Yukihiko,
Imoto Masumi,
Toda Akihisa,
Kashige Nobuhiro,
Miake Fumio
Publication year - 2013
Publication title -
microbiology and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 70
eISSN - 1348-0421
pISSN - 0385-5600
DOI - 10.1111/1348-0421.12035
Subject(s) - pyriproxyfen , alum , immune system , ovalbumin , biology , juvenile hormone , immunology , endocrinology , hormone , chemistry , pesticide , organic chemistry , agronomy
Pyriproxyfen is a juvenile hormone mimic of vital importance for insect development with little risk to humans. This study was performed to investigate whether large doses of pyriproxyfen affect the immune response in mammals. Mice were immunized thrice with ovalbumin in 5% ethanol, with or without pyriproxyfen or alum. Large doses of pyriproxyfen (9 or 15 mM) significantly enhanced specific total IgG immune response. This enhancement was no longer present 24 hr after treatment with pyriproxyfen. These results suggest that pyriproxyfen is a safe chemical. Moreover, pyriproxyfen induced higher titers of IgG2a and enhanced tumor necrosis factor‐alpha and gamma‐interferon responses whereas alum induced IgG1 with enhanced interleukin‐4 and ‐10. These observations indicate that the mechanism of immune enhancement by pyriproxyfen may differ from that of alum.