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Case series of elderly patients with scabies topically applied with ivermectin via whole‐body bathing
Author(s) -
Komoda Masayo,
Miyajima Atsushi,
Koshino Machi,
Akutsu Shunta,
Yamada Mizuki,
Ozeki Rie,
Makigami Kuniko
Publication year - 2021
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15746
Subject(s) - ivermectin , bathing , scabies , medicine , adverse effect , dermatology , cure rate , confidence interval , surgery , pathology , veterinary medicine
As a novel method of ivermectin (IVM) administration for the treatment of scabies, we devised a whole‐body bathing (WBB), in which patients are immersed in a fluid that contains IVM. A multi‐institutional trial for elderly patients with scabies was conducted to investigate the efficacy and safety of IVM‐WBB. Seven elderly patients with scabies were enrolled and received IVM‐WBB up to four times at 1‐week interval. The cure for scabies was defined as the absence of mites in two consecutive microscopic or dermoscopic examinations at weekly intervals and the absence of new skin lesions indicative of scabies. Consequently, the cure rate on day 22, the primary end‐point, was 71.4%, and all patients had been cured until day 29. Additionally, neither significant adverse events nor clinically problematic abnormal blood test values were obtained. Furthermore, no IVM was detected in the optional plasma (five cases) collected for IVM measurement after bathing. These results suggest that IVM‐WBB was effective to treat scabies, causing no serious adverse events and with a very low internal exposure of IVM.