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Dermatological manifestations during COVID‐19 and histological picture: Description of two clinical cases
Author(s) -
Mencarini Paola,
Scarabello Alessandra,
Del no Franca,
Lalle Eleonora,
Falasca Laura,
Gualano Gina,
Nardacci Roberta,
Mosti Silvia,
Musso Maria,
Libertone Raffaella,
Di Bari Virginia,
Rosati Silvia,
Colombo Daniele,
Castilletti Concetta,
Palmieri Fabrizio
Publication year - 2021
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15714
Subject(s) - covid-19 , medicine , pathology , dermatology , disease , outbreak , infectious disease (medical specialty)
It is not yet entirely clear what is the relevance of skin symptoms and what clinical implications are related to their appearance in COVID‐19 patients. We describe two cases of COVID‐19‐associated pneumonia, which presented skin manifestations in advanced stage of illness, when nasopharyngeal swabs became negative for SARS‐CoV‐2. The first case presented erythematous, maculopapular lesions; the second developed petechial, vesicular and blood‐encrusted lesions on the limbs. Histopathology documented perivascular lymphocytic infiltrates, with prevalent CD4+ T‐cells in both patients. The research of SARS‐CoV‐2 in tissues with real time RT‐PCR was negative. Basal keratinocytes displayed C4d deposits in one case, who developed laboratory signs indicative of a procoagulative condition at the same time as the skin rash. Skin manifestations during SARS‐CoV‐2 infection seem to be clinically relevant and further studies are necessary to assess if they are linked to systemic complications, lack of viral clearance or cascades of immune responses induced by the virus, even in patients affected by mild pneumonia.