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Toxic epidermal necrolysis induced by human herpesvirus 7 treated with a tumor necrosis factor‐α inhibitor
Author(s) -
Shen MengHan,
Liu MingTsan,
Chung WenHung,
Lu ChunWei
Publication year - 2020
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15493
Subject(s) - toxic epidermal necrolysis , medicine , disease , virus , dermatology , immunology , human herpesvirus 6 , tumor necrosis factor alpha , pathology , herpesviridae , viral disease
Abstract Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is a life‐threatening hypersensitivity reaction. Long‐term sequelae include dry eyes, visual impairment and psychological complications. TEN is mostly induced by medication; however, viral infections, such as coxsackievirus A6, are known triggers of this disease. However, how to define the role of infection in SJS/TEN is still a problem. Most patients develop SJS/TEN over the course of symptoms of the infection first, and then take medication. Therefore, virus culture and nucleic acid detection at the acute stage cannot predict that the virus itself will indeed produce such a serious reaction. Furthermore, many SJS/TEN patients who are diagnosed with an infection are afraid of receiving the drug rechallenge test. Thus, we report the first case worldwide of a patient who suffered from TEN caused by herpesvirus 7 infection, which was confirmed by both real‐time polymerase chain reaction and lymphocyte transformation test.