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Nitrogen mustard gel‐induced inflammation triggers lymphomatoid papulosis in patients with mycosis fungoides
Author(s) -
Trager Megan H.,
Chen Cynthia,
Husain Sameera,
Geskin Larisa J.
Publication year - 2020
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15276
Subject(s) - lymphomatoid papulosis , mycosis fungoides , nitrogen mustard , inflammation , medicine , pathogenesis , cutaneous t cell lymphoma , cd30 , pathology , dermatology , lymphoma , immunology , chemotherapy , cyclophosphamide
Lymphomatoid papulosis (LyP) is a paraneoplastic primary cutaneous CD30 + lymphoproliferative disorder (LPD) that has been associated with malignant lymphomas, most commonly mycosis fungoides (MF). We observed 10 patients with MF who developed severe inflammation after using nitrogen‐mustard (NM) gel from 1 to 8 months and who developed LyP. We hypothesized that NM gel produced local inflammation, which induced CD30 expression in malignant T cells in situ leading to the appearance of LyP papules. The high frequency of induction of LyP lesions in patients with severe inflammation while on treatment with NM gel suggests an association between inflammatory stimuli and development of LyP. Our observation provides insight into the pathogenesis of CD30 + LPD.