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Retrospective study of photodynamic therapy for pulsed dye laser‐resistant port‐wine stains
Author(s) -
Han Yue,
Ying Hanru,
Zhang Xiaolin,
Yu Wenxin,
Cen Qingqing,
Chen Xuanfeng,
Qiu Yajing,
Chen Hui,
Jin Yunbo,
Ma Gang,
Lin Xiaoxi
Publication year - 2020
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15238
Subject(s) - photodynamic therapy , port wine stain , blanching , port wine , medicine , dye laser , adverse effect , dermatology , surgery , laser , optics , chemistry , physics , organic chemistry , food science
Pulsed dye laser‐resistant port‐wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser‐resistant cervicofacial port‐wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532‐nm light. For objective evaluation of photodynamic therapy efficacy, first, the colorimetric changes in the port‐wine stain lesions were evaluated according to the L * a * b * color coordinate system, then the values of color changes (Δ E ) and blanching rate were calculated. For subjective evaluation of improvement, photographs taken before and after photodynamic therapy were evaluated by three independent assessors blindly. Patient satisfaction was also used as a factor in the subjective evaluation. Adverse events were recorded after treatment. The median Δ E decreased significantly from the pretreatment value of 13.42 to 9.90 at the 2‐month follow up ( P < 0.001). The median blanching rate of port‐wine stains was 28.04% after an average of 1.21 sessions of photodynamic therapy. Based on the overall visual assessment, 46.2% patients showed excellent or good levels of improvement (>50% color blanching). Adverse events were minimal, transient and self‐limiting. In conclusion, photodynamic therapy serves as an alternative means to treat pulsed dye laser‐resistant port‐wine stains.