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Case of autoimmune progesterone dermatitis presenting as necrotic migratory erythema successfully controlled by danazol
Author(s) -
Zhang Manfeng,
Tang Xuhua,
Zhou Hui,
Liao Qiman,
Han Jiande
Publication year - 2020
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15180
Subject(s) - dermatology , medicine , danazol , erythema , erythema multiforme , acne , drug eruption , angioedema , labia majora , pathology , endometriosis , vulva , drug , psychiatry
Autoimmune progesterone dermatitis (APD) is a rare cutaneous disorder with cyclic skin eruptions during the luteal phase of the menstrual cycle. Patients can present with various clinical manifestations, including urticaria and angioedema, erythema multiforme, eczema, fixed drug eruption and centrifugal erythema annulare. In our case, however, the patient’s skin lesions mimic necrotic migratory erythema (NME) which is most commonly associated with glucagonoma and rarely with liver disease, inflammatory bowel disease, malnutrition and other tumors. To our knowledge, this is the first case of NME‐like APD and is successfully controlled by danazol. This also sheds lights on the etiologic diversity of NME.