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Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15‐year nationwide population‐based cohort study
Author(s) -
Jung Keum Ji,
Kim TaeGyun,
Lee Jae Won,
Lee Minseok,
Oh Jongwook,
Lee SangEun,
Chang HyukJae,
Jee Sun Ha,
Lee MinGeol
Publication year - 2019
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15052
Subject(s) - medicine , psoriasis , hazard ratio , population , cohort , proportional hazards model , cohort study , myocardial infarction , retrospective cohort study , incidence (geometry) , disease , confidence interval , immunology , environmental health , physics , optics
The association between psoriasis and risk of atherosclerotic cardiovascular disease has not been thoroughly evaluated in a large longitudinal cohort of an Asian population. We conducted a nationwide population‐based retrospective cohort study encompassing more than 1.7 million Koreans with a 15‐year follow‐up period. The period prevalence of psoriasis was 0.33% among the baseline participants (1997–2000). In Cox proportional hazard analyses, the individuals with psoriasis had a higher adjusted hazard ratio (HR) for incidence of overall atherosclerotic cardiovascular disease (HR, 1.18; 95% confidence interval [CI], 1.09–1.27) compared with controls. Subgroup analyses revealed that the risk for myocardial infarction was commonly increased in both sexes with moderate to severe psoriasis (male: HR, 2.09; 95% CI, 1.35–3.24; female: HR, 3.23; 95% CI, 1.34–7.76), whereas the risk for ischemic stroke was specifically increased in female individuals with moderate to severe psoriasis (HR, 2.02; 95% CI, 1.24–3.30). Our data suggest that appropriate medical screening for possible cardiovascular comorbidities is warranted in Asian psoriatic patients according to disease severity and sex.