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Tacrolimus ointment for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma
Author(s) -
Zhang Xuepeng,
Yang Kaiying,
Chen Siyuan,
Ji Yi
Publication year - 2019
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.15031
Subject(s) - medicine , tacrolimus , dermatology , hemangioendothelioma , surgery , radiology , transplantation
Abstract Kaposiform hemangioendothelioma ( KHE ) and tufted angioma ( TA ) are rare infiltrative vascular tumors. Currently, no standard treatment regimens exist for KHE / TA . The purpose of our study was to evaluate the efficacy and safety of topical application of tacrolimus for superficial KHE / TA . We examined six patients with superficial KHE / TA . All patients were treated with tacrolimus 0.1% ointment twice daily for at least 12 months. The response rate was 100%, including three nearly complete remissions. Only one patient experienced local pruritus during treatment. The data constituted an intriguing rationale for clinical trials of topical tacrolimus in the treatment of superficial KHE / TA .