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Overexpression of cyclin‐dependent kinase 4 protein in extramammary Paget's disease
Author(s) -
Urata Kazumi,
Kajihara Ikko,
Myangat Tselmeg Mijiddorj,
Tasaki Yukino,
OtsukaMaeda Saki,
Sawamura Soichiro,
KanazawaYamada Saori,
Sakamoto Ryoko,
Makino Katsunari,
Aoi Jun,
Igata Toshikatsu,
Makino Takamitsu,
Masuguchi Shinichi,
Fukushima Satoshi,
Jinnin Masatoshi,
Ihn Hironobu
Publication year - 2019
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14858
Subject(s) - extramammary paget's disease , cancer research , kinase , cyclin , disease , protein kinase a , medicine , biology , microbiology and biotechnology , cancer , cell cycle
Cyclin‐dependent kinase 4 and 6 ( CDK 4/6) plays an important role in cell cycle progression, and the CDK 4/6–cyclin D1 complex controls the cell cycle transition from G 1 phase to S phase. CDK 4 is enhanced in several types of cancers and CDK 4/6 inhibitors attenuate the proliferation of several types of cancer in vitro / in vivo . The purpose of our study was to investigate the expression pattern of CDK 4 and evaluate its clinical importance in extramammary Paget's disease (EMPD). Almost all EMPD tissues were positive for CDK 4, and metastatic lesions had a similar immunostaining intensity to primary lesions. In addition, CDK 4 protein levels were positively correlated with those of cyclin D1 protein. Taken together, CDK 4 may assume a crucial role in EMPD progression.