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Moderate to severe atopic dermatitis ( AD ) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long‐term disease control in the Japanese population.  ADDRESS ‐J is a non‐interventional, observational registry of adult Japanese patients with moderate to severe  AD . Herein, we report baseline data from the  ADDRESS ‐J study describing disease characteristics and current treatment practices. At baseline, 300 adult  AD  patients with Investigator's Global Assessment ( IGA ) scores (range, 0–4) of 3 (moderate) or 4 (severe) whose treatments for  AD  were intensified, were assessed for clinical and patient‐reported outcomes and current  AD  treatments. The registry patients’ median age was 34.0 years; 60.7% were male and 71.7% had had  AD  for more than 20 years. At baseline, 220 study patients had an  IGA  score of 3 and 80 had an  IGA  score of 4. The median Eczema Area and Severity Index score was 21.7 (range, 0–72), the median body surface area involvement was 46.25%, and the median pruritus numerical rating scale score was 7.0 (range, 0–10); for each of these measures, higher scores represent greater severity. Most registry patients (86.7%) had recently used topical corticosteroids or topical calcineurin inhibitors as treatment for  AD . This registry cohort represents a population of Japanese patients with moderate to severe  AD  and provides an important resource for characterizing the disease burden and evaluating the safety and effectiveness of various  AD  treatments.

the journal of dermatology

Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis ( ADDRESS ‐J): Baseline characteristics, treatment history and disease burden