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Pembrolizumab resolves adult ashy dermatosis developing in patients with squamous cell carcinoma of the lung
Author(s) -
Takeda Kana,
Fujimura Taku,
Tsuchiyama Kenichiro,
Lyu Chunbing,
Aiba Setsuya
Publication year - 2019
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14775
Subject(s) - pembrolizumab , pathology , medicine , squamous cell carcinoma of the lung , cytotoxic t cell , immunohistochemistry , carcinoma , lung cancer , basal cell , dermatology , biology , cancer , immunotherapy , in vitro , biochemistry
Ashy dermatosis is a rare cutaneous disorder of unknown etiology. We describe a case of adult ashy dermatosis developing in a patient with squamous cell carcinoma of the lung, which was resolved by the administration of pembrolizumab in parallel with multiple vitiligo. Interestingly, immunohistochemical staining revealed that lesional skin of the ashy dermatosis contained cytotoxic T cells and programmed death ligand 1 expressing cells. To our knowledge, this is the first case of adult ashy dermatosis resolved by pembrolizumab.