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Estrogen dermatitis: Case report and examination of estrogen receptor‐β in the skin
Author(s) -
Fukayama Maiko,
Asano Yoshihide,
ShinozakiUshiku Aya,
Sato Shinichi
Publication year - 2019
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14750
Subject(s) - estrogen , medicine , estrogen receptor , exacerbation , menstrual cycle , pathological , inflammation , hormone , physiology , endocrinology , dermatology , cancer , breast cancer
Many women experience some skin reaction or trouble in their monthly menstrual cycle, including the exacerbation of pre‐existing diseases and skin eruptions directly associated with sex hormones. We herein report a Japanese woman who experienced repeated systemic urticaria in her premenstrual period, and was diagnosed as having estrogen dermatitis based on a positive result of intradermal estrogen skin test. Of note, the expression of estrogen receptor‐β was increased in small dermal vessels of this case as well as in those of patients with other inflammatory skin diseases. These results suggest that inflammation may induce estrogen receptor‐β expression in small dermal vessels, which potentially modifies the pathological skin inflammation during the menstrual period, leading to the development of estrogen dermatitis.