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Onychomycosis caused by Aspergillus subramanianii
Author(s) -
Hirose Miki,
Noguchi Hiromitsu,
Yaguchi Takashi,
Matsumoto Tadahiko,
Hiruma Masataro,
Fukushima Satoshi,
Ihn Hironobu
Publication year - 2018
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14616
Subject(s) - aspergillus , terbinafine , hypha , aspergillosis , pathology , septate , mycosis , conidium , biology , fungus , dermatology , medicine , microbiology and biotechnology , itraconazole , botany , antifungal , immunology
We describe a case of a 23‐year‐old female patient with no apparent underlying diseases. She showed a discoloration of the proximal portion of the left big toenail with paronychia. Direct microscopy revealed septate hyphae with conidiophores, and a periodic acid–Schiff‐stained nail specimen revealed septate hyphae branching at angles of approximately 45°. On the basis of phylogenetic analysis, we finally arrived at the diagnosis of ungual aspergillosis caused by Aspergillus subramanianii . After p.o. administration of terbinafine and topical application of 10% efinaconazole solution, the disease resolved in 6 months. A. subramanianii is one of the new species in the genus Aspergillus section Circumdati . Reported clinical isolates have been isolated from lung tissue, wounds and feet. This is the first documented case of onychomycosis caused by A . subramanianii . Onychomycosis due to Aspergillus species is uncommon. We summarized the reported cases of ungual aspergillosis in Japan.