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Identification of a human papillomavirus type 58 lineage in multiple Bowen's disease on the fingers: Case report and published work review
Author(s) -
Kobayashi Kenta,
Tanese Keiji,
Kubo Akiharu,
MatsumotoMochimaru Naoko,
Sasaki Aya,
Kameyama Kaori,
Amagai Masayuki,
UmegakiArao Noriko
Publication year - 2018
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14574
Subject(s) - bowen's disease , human papillomavirus , sanger sequencing , carcinogenesis , disease , dermatology , skin cancer , biology , hpv infection , virology , cervical cancer , medicine , cancer , pathology , dna sequencing , gene , genetics , basal cell
Human papillomavirus ( HPV ) has been detected in some cases of Bowen's disease, particularly on the fingers and genitalia. HPV ‐58 is classified as a high‐risk mucosal type and accounts for a high percentage of cervical cancer in Asia. Moreover, several HPV ‐58 lineages, including sublineage A1, have a high prevalence in Asia. However, the nature of HPV ‐58‐associated skin cancer is still unknown. Here, we report a case of a Japanese patient with multiple Bowen's disease on the fingers. A 33‐year‐old man presented with multiple reddish‐brown scaly plaques on his left middle finger and right ring finger. All lesions were surgically excised, and the diagnosis of Bowen's disease was made. We performed Sanger sequencing using DNA extracted from paraffin‐embedded samples and identified HPV ‐58 sublineage A1. Additionally, we review previous reports on HPV ‐58‐associated skin cancers, including our case, showing a high regional prevalence in Asia. Further studies would be needed to reveal the relationship between HPV ‐58 lineages and carcinogenesis in the skin.