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Analysis of possible structures of inducible skin‐associated lymphoid tissue in lupus erythematosus profundus
Author(s) -
Kogame Toshiaki,
Yamashita Ryosuke,
Hirata Masahiro,
Kataoka Tatsuki R.,
Kamido Hisashi,
Ueshima Chiyuki,
Matsui Miho,
Nomura Takashi,
Kabashima Kenji
Publication year - 2018
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14498
Subject(s) - germinal center , lymphatic system , pathology , biology , dermis , immunohistochemistry , high endothelial venules , immunology , medicine , b cell , antibody
Lupus erythematosus profundus ( LEP ) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. LEP is characterized by the presence of lymphoid follicles ( LF ) and germinal centers ( GC ). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs ( TLO ). Previously, we identified dynamically orchestrated cellular elements in murine contact dermatitis that resembled lymphoid structures, which we termed inducible skin‐associated lymphoid tissues ( iSALT ). We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans. Here, we studied ectopic lymphoid tissues in the lesions of LEP by immunohistochemistry and compared their characteristics with those of TLO . We demonstrated that LF of LEP were composed of B‐cell follicles intermingled with CXCL 13‐expressing cells, distinct aggregations of T cells, and some blood vessels expressing peripheral node addressin. These findings indicate that LF of LEP can be considered as a type of iSALT .