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Decrease in eosinophils infiltrating into the skin of patients with dipeptidyl peptidase‐4 inhibitor‐related bullous pemphigoid
Author(s) -
Chijiwa Chika,
Takeoka Shintaro,
Kamata Masahiro,
Tateishi Mihoko,
Fukaya Saki,
Hayashi Kotaro,
Fukuyasu Atsuko,
Tanaka Takamitsu,
Ishikawa Takeko,
Ohnishi Takamitsu,
Watanabe Shinichi,
Tada Yayoi
Publication year - 2018
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14245
Subject(s) - bullous pemphigoid , medicine , dipeptidyl peptidase 4 , dipeptidyl peptidase 4 inhibitor , linagliptin , eosinophil , dipeptidyl peptidase , gastroenterology , pemphigoid , autoantibody , diabetes mellitus , immunology , endocrinology , antibody , type 2 diabetes , chemistry , biochemistry , enzyme , asthma
Bullous pemphigoid ( BP ) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as BP 180 or BP 230 are produced. Dipeptidyl peptidase ( DPP )‐4 inhibitors have become commonly used to treat diabetes. As DPP ‐4 inhibitors are more commonly prescribed for diabetes, BP related to DPP ‐4 inhibitors has been reported and has attracted attention. Therefore, we retrospectively investigated patients who were diagnosed with BP in order to examine characteristics of DPP ‐4 inhibitor‐related BP (nine patients; median age, 85 years) in comparison with non‐ DPP ‐4 inhibitor‐related BP (21; median age, 85 years). There was no significant difference in Bullous Pemphigoid Disease Area Index between DPP ‐4 inhibitor‐related BP patients and non‐ DPP ‐4 inhibitor‐related BP patients, except for erosions/blisters score in mucosa. Laboratory tests revealed no significant differences between DPP ‐4 inhibitor‐related BP patients and non‐ DPP ‐4 inhibitor‐related BP patients in total white blood cell count, eosinophil count, neutrophil count and the titer of anti‐ BP 180 antibody. The number of eosinophils infiltrating into the skin was significantly lower in patients with DPP 4 inhibitor‐related BP than in patients with non‐ DPP 4 inhibitor‐related BP . Our results showed that DPP ‐4 inhibitor‐related BP has some distinct pathological characteristics from BP not associated with DPP ‐4 inhibitor.