Premium
Two cases of infundibular squamous cell carcinoma on the nose with aggressive clinical behavior: Case report and review of the published work
Author(s) -
Kiyohara Takahiro,
Nakamaru Sei,
Nagano Naoko,
Terai Sayaka,
Makimura Kaoru,
Suzuki Kenji,
Iwai Hiroshi,
Tanimura Hirotsugu
Publication year - 2018
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.14131
Subject(s) - pathology , nose , nodule (geology) , metastasis , biology , anatomy , medicine , cancer , paleontology , genetics
Case 1 was a 75‐year‐old Japanese man who presented with a poorly demarcated, dark‐red nodule with a destructive defect in the center, measuring 3 cm × 2 cm on the right wing of his nose. The histological diagnosis was a common form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the wall of a follicular infundibulum. The majority of neoplastic cells were positive for AE 1/ AE 3 and 34βE12. Cytokeratin 17 expression was seen in the suprabasal cells of the deeply situated neoplastic components. Case 2 was a 73‐year‐old Japanese man who presented with a poorly demarcated, dark‐red nodule with an irregularly shaped ulcer in the center, measuring 3 cm × 2 cm on the left wing of his nose. The histological diagnosis was a crater form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the broad base of the central keratin‐filled crater, continuous with two infundibular canals. In both cases, some of the more deeply situated aggregations were composed of neoplastic keratinocytes with eosinophilic glassy or pale cytoplasm. In addition, no atypical keratinocytes could be seen in the interfollicular epidermis. In case 1, a hematogenous metastasis to the vocal cord and the forehead occurred in addition to a lymph node metastasis. In case 2, a local recurrence occurred with an intralymphatic dissemination. We describe two cases of infundibular squamous cell carcinoma on the nose with aggressive clinical behavior, one of which was accompanied by a hematogenous metastasis while another revealed a local recurrence.