Premium
Pseudoangiosarcomatous squamous cell carcinoma of the skin: A need for a more rigorous nomenclature for histopathological variants of squamous cell carcinoma
Author(s) -
AlegríaLanda Victoria,
NavarroTriviño Francisco Jose,
AneirosFernandez Jose,
Requena Luis
Publication year - 2018
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13997
Subject(s) - basal cell , pathology , nomenclature , medicine , cancer research , oncology , biology , zoology , taxonomy (biology)
Over the years, squamous cell carcinomas ( SCC ) that mimicked vascular lesions have been encompassed within different classifications and the underlying etiopathogenic mechanisms have been interpreted in different ways by different authors. Here, we present a case of SCC with pseudovascular areas in the right leg of a 96‐year‐old woman with chronic venous insufficiency. Histopathological examination closely resembled an angiosarcoma, but the immunohistochemical negativity for endothelial markers and the strong positivity for the pancytokeratin marker AE 1/ AE 3 revealed the epithelial nature of the neoplasm. After a comprehensive review of all similar previously published cases, we believe that it is necessary to separate SCC with pseudoluminal structures composed of glandular‐like areas (pseudoglandular or adenoid SCC ) from those mimicking vascular lumina (pseudovascular and pseudoangiosarcomatous SCC ). We would like to emphasize that acantholytic SCC , a definitive variant of SCC , can be further classified into the common or ordinary subtype of acantholytic SCC , that shows solid nests containing numerous acantholytic atypical keratinocytes without any mimickers for specific structures, and pseudoglandular, pseudovascular and pseudoangiosarcomatous subtypes when glandular or vascular structures are mimicked, respectively.