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Topical treatment with sacran, a sulfated polysaccharide from Aphanothece sacrum , improves corneocyte‐derived parameters
Author(s) -
Doi Moeko,
Sagawa Yuki,
Momose Shigeyoshi,
Tanaka Takumi,
Mizutani Taeko,
Okano Yuri,
Masaki Hitoshi
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13970
Subject(s) - transepidermal water loss , polysaccharide , penetration (warfare) , chemistry , stratum corneum , biophysics , medicine , biochemistry , biology , pathology , operations research , engineering
Abstract Sacran, a polysaccharide isolated from Aphanothece sacrum ( Suizenji‐nori ) alga, has unique characteristics in terms of its physiological properties and effects on the skin, and has recently become a focus of attention as a novel biomaterial. In a previous study, we reported the unique physical characteristics of sacran, which forms a gel‐like film containing water in the presence of polyols. This film resists penetration by water and chemicals. We expected this unique physical characteristic to act as an artificial barrier upon the application of sacran to the skin. In the present study, we tested the efficacy of sacran application in healthy individuals who reported previous symptoms of dry or inflamed skin, to evaluate the potential benefits of sacran for skin care in patients with mild atopic dermatitis. Compared with placebo, sacran‐containing serum did not significantly alter either the water content of the skin surface or transepidermal water loss. However, subjects using the serum showed improvements in corneocyte parameters including size, percentage of thick abrasion, ratio of SH to SS groups, ratio of interleukin (IL)‐1 receptor antagonist to IL‐1α, and carbonylated protein level. These results indicate that the sulfated polysaccharide sacran is an effective agent for improving or maintaining the skin conditions.