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Unexpected recalcitrant course of drug‐induced erythema multiforme‐like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy
Author(s) -
Nomura Hisashi,
Takahashi Hayato,
Suzuki Satsuki,
Kurihara Yuichi,
Chubachi Shotaro,
Kawada Ichiro,
Yasuda Hiroyuki,
Betsuyaku Tomoko,
Amagai Masayuki,
Funakoshi Takeru
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13810
Subject(s) - nivolumab , vemurafenib , medicine , ipilimumab , erythema , adverse effect , erythema multiforme , melanoma , dermatology , immunology , drug eruption , pneumonia , immunotherapy , oncology , drug , immune system , cancer research , pharmacology , metastatic melanoma
Vemurafenib improves survival of melanoma patients. However, cutaneous side‐effects commonly occur in them. Nivolumab and ipilimumab are monoclonal antibodies against programmed death 1 and cytotoxic T‐lymphocyte‐associated antigen 4, both of which regulate excessive T‐cell activation. Although these agents induce antitumor immunity against melanoma, the modified immune condition may result in an unexpected adverse reaction which has not been observed previously. Herein, we report a case who manifested severe erythema multiforme‐like eruption with mucosal involvement associated with vemurafenib following nivolumab. The patient also subsequently suffered from ipilimumab‐induced interstitial pneumonia with refractory course. Such a case has never been reported. This case suggested that dermatologists should pay special attention to unexpected adverse events of these drugs, and carefully observe cutaneous and respiratory status of patients during the treatment of melanoma.