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Relapsing polychondritis associated with psoriasis vulgaris successfully treated with adalimumab: A case report with published work review
Author(s) -
Matsuo Haruka,
Asahina Akihiko,
Fukuda Takeshi,
Umezawa Yoshinori,
Nakagawa Hidemi
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13796
Subject(s) - medicine , psoriasis , relapsing polychondritis , adalimumab , subclinical infection , erythema , biopsy , dermatology , inflammation , cartilage , pathology , disease , anatomy
Relapsing polychondritis (RP) is a rare autoimmune‐mediated disease characterized by inflammation involving cartilaginous tissues. We report here a case of RP in a 38‐year‐old Japanese man with 13‐year duration of psoriasis vulgaris treated with topical steroids and vitamin D 3 . The patient presented with tender swelling and erythema of both auricles, and the antibody to type II collagen was detected. The biopsy specimen revealed a dense mixed cell infiltration over the auricular cartilage. We reviewed eight cases with the association of RP and psoriasis, and in all cases the clinical course of psoriasis did not correlate with that of RP. The severity of RP was mild in the majority of cases, and our case was unique in that the patient had no joint symptoms. Adalimumab treatment was effective for both RP and psoriasis. Fat‐suppressed contrast‐enhanced magnetic resonance imaging was beneficial, not only to demonstrate subclinical inflammation in the nasal septum, but also to subjectively assess the improvement of RP.