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Elevated transglutaminase‐2 expression in the epidermis of psoriatic skin and its role in the skin lesion development
Author(s) -
Su ChingChyuan,
Su TzuRong,
Lai JiChing,
Tsay GregoryJ,
Lin HungKe
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13742
Subject(s) - psoriasis , stratum granulosum , immunohistochemistry , epidermis (zoology) , staining , keratinocyte , pathology , tissue transglutaminase , basal (medicine) , medicine , angiogenesis , lesion , dermatology , biology , anatomy , in vitro , stratum corneum , enzyme , biochemistry , insulin
Psoriasis, an inflammatory skin disease triggered by the immune system, presents keratinocyte hyperproliferation, differentiation and angiogenesis. The role of transglutaminase‐2 ( TG 2) in psoriasis has not been fully established yet. In this retrospective, non‐randomized and non‐blinded study, skin biopsies were collected from 37 psoriatic patients and immunohistochemical staining was performed. TG 2 staining was positive in all 37 samples, among which 32 were strong and five weak. The localization of TG 2 staining was present in the epidermis and spreading from basal layer to stratum granulosum in decreasing staining intensity. However, TG 2 was also expressed in the basal layer in the non‐lesional site of psoriasis and the skin of healthy people. The presence of TG 2 was not associated with disease duration, stage of disease and subtype of psoriasis. Overexpression of TG 2 seems to be an important role in psoriatic development.