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Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas
Author(s) -
Kagimoto Yoshiko,
Yamasaki Kenshi,
ShimadaOhmori Ryoko,
Nan Liu,
Numata Yukikazu,
Aiba Setsuya
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13726
Subject(s) - leiomyoma , medicine , calcitonin gene related peptide , uterine leiomyoma , smooth muscle , prostaglandin e2 , nociception , receptor , pathology , neuropeptide
Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE 2, BDKRB 2, VR 1 and CGRP . We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1‐cm in diameter, which caused severe pain diffused throughout an area of 20‐cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP , PGE 2 and VR 1 in this case. We found a positive correlation between VR 1 and PGE 2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR 1 and PGE 2 might be key algogenic substances in painful leiomyoma.