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Successful treatment of multiple in‐transit melanomas on the leg with intensity‐modulated radiotherapy and immune checkpoint inhibitors: Report of two cases
Author(s) -
Fujimura Taku,
Kambayashi Yumi,
Furudate Sadanori,
Hidaka Takanori,
Sato Yota,
Tanita Kayo,
Tono Hisayuki,
Tsukada Akira,
Hashimoto Akira,
Aiba Setsuya
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13707
Subject(s) - ipilimumab , nivolumab , cyberknife , medicine , immune checkpoint , oncology , melanoma , radiation therapy , immunotherapy , cancer research , radiosurgery , cancer
Because the efficacy rates of monotherapy with immune checkpoint inhibitors such as nivolumab or ipilimumab are not sufficient, to enhance the antitumor effects of these reagents is of great interest among dermato‐oncologists. In this report, we describe two cases of multiple in‐transit metastatic melanomas on the leg successfully treated with intensity‐modulated radiotherapy ( IMRT ) using a CyberKnife in combination with ipilimumab or nivolumab. Our cases suggested that IMRT could enhance the antitumor effects of immune checkpoint inhibitors in patients with multiple in‐transit melanomas.