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Two cases of seborrheic keratosis with basal clear cells
Author(s) -
Anan Takashi,
Fukumoto Takaya,
Kimura Tetsunori
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13641
Subject(s) - seborrheic keratosis , basal (medicine) , pathology , cytokeratin , immunohistochemistry , keratosis , dermatology , epidermis (zoology) , biology , medicine , anatomy , insulin
Seborrheic keratosis with basal clear cells ( SKBCC ) is an extremely rare histopathological variant of seborrheic keratosis that has histological similarities to melanoma in situ . We herein report two cases of SKBCC and provide the first description of the dermoscopic features of this condition, in addition to the histopathological findings. Both of the two lesions showed typical histological architectures of seborrheic keratosis with rows or focal clusters of monomorphic clear cells with abundant pale cytoplasm and small round nucleus in the basal layer. Immunohistochemical examination revealed that most clear cells were positive for high molecular weight cytokeratin (34βE12) in a peripheral pattern but were negative tor Melan‐A. Dermoscopy revealed typical features of ordinary seborrheic keratosis, while unfortunately did not reflect the presence of basal clear cells.