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Pharmacokinetics of ivermectin applied topically by whole‐body bathing method in healthy volunteers
Author(s) -
Miyajima Atsushi,
Hirota Takashi,
Tashiro Mari,
Noguchi Wataru,
Kawano Yayoi,
Hanawa Takehisa,
Kigure Akira,
Anata Taichi,
Yamamoto Yosuke,
Yuasa Nae,
Koshino Machi,
Shiraishi Yumi,
Yuzawa Kaoru,
Akagi Keita,
Yoshimasu Takashi,
Makigami Kuniko,
Komoda Masayo
Publication year - 2017
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13628
Subject(s) - bathing , stratum corneum , ivermectin , medicine , scabies , adverse effect , pharmacokinetics , clinical trial , anesthesia , pharmacology , dermatology , pathology , veterinary medicine
As a novel administration method of ivermectin ( IVM ) for scabies treatment, we proposed a “whole‐body bathing method ( WBBM )”. In this method, the patients would bathe themselves in a bathing fluid containing IVM at an effective concentration. Previously, we demonstrated that WBBM could deliver IVM to the skin but not to the plasma in rats. In the present study, to assess the clinical validity of the method an arm bathing examination (first trial) and a whole‐body bathing examination (second trial) were conducted in healthy volunteers. In both the first and second trials, after bathing in fluid containing IVM , the exposure in the stratum corneum was higher compared with that after taking IVM p.o. as reported previously. IVM was not detected in plasma at any sampling point after the whole‐body bathing in the second trial. Furthermore no serious adverse events were found. These results in both trials suggest that WBBM can deliver IVM to the human stratum corneum without systemic exposure or serious adverse effects in healthy volunteers, and at concentrations that would be adequate for scabies treatment.