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Hereditary lactate dehydrogenase M‐subunit deficiency with late‐developing pustular psoriasis‐like lesions
Author(s) -
Takeo Naoko,
Fujiwara Sakuhei,
Sakai Takashi,
SaitoShono Tomoko,
Ishikawa Kazushi,
Hatano Yutaka
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13516
Subject(s) - pustular psoriasis , medicine , lactate dehydrogenase , psoriasis , protein subunit , dermatology , pathology , enzyme , biology , biochemistry , gene
Hereditary lactate dehydrogenase ( LDH ) M‐subunit deficiency is very rare and we have found reports of close to a dozen cases in the published work, two of which were associated with pustular psoriasis‐like lesions. We report a third case of pustular psoriasis‐like eruptions associated with LDH M‐subunit deficiency, which occurred 24 years after the diagnosis of LDH M‐subunit deficiency. These cases indicate that abnormal activity of LDH can induce pustular psoriatic lesions in the long term. Some patients with symptoms of hereditary LDH M‐subunit deficiency have antecedent annular scaly plaque lesions, that resemble psoriatic lesions. We discuss a hypothesis to explain this scenario.