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Merkel cell carcinoma associated with stable chronic hemodialysis: A report of two cases
Author(s) -
Nagase Kotaro,
Kimura Hiromi,
Ogawa Shizuka,
TaraHashimoto Akiko,
Koba Shinichi,
Inoue Takuya,
Narisawa Yutaka
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13494
Subject(s) - merkel cell carcinoma , hemodialysis , medicine , oncology , renal cell carcinoma , carcinoma , cancer research
Abstract Merkel cell carcinoma ( MCC ) is a rare but aggressive cutaneous malignancy associated with the Merkel cell polyomavirus ( MCP yV). Multiple studies have shown that the incidence of MCC is higher among immunocompromised individuals than among the general population. In fact, immunosuppressed individuals account for approximately 10% of the MCC patient population. In this report, we describe two cases of MCP yV‐related MCC in Japanese patients on hemodialysis. In both the cases, MCC was present on the face. Both cellular and humoral immunities have been shown to be decreased in uremic patients, and dialysis patients have a high risk of viral‐mediated cancers, including human papillomavirus‐associated cancers. Immune dysfunction related to uremia and dialysis may be associated with a high risk of developing MCC .