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Levels of immunoglobulin E specific to the major food allergen and chemokine (C‐C motif) ligand ( CCL )17/thymus and activation regulated chemokine and CCL 22/macrophage‐derived chemokine in infantile atopic dermatitis on I shigaki I sland
Author(s) -
Esaki Hitokazu,
Takeuchi Satoshi,
Furusyo Norihiro,
Yamamura Kazuhiko,
Hayashida Sayaka,
Tsuji Gaku,
Takemura Masaki,
Hayashi Jun,
Furue Masutaka
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13360
Subject(s) - ccl22 , immunoglobulin e , immunology , chemokine , ccl17 , allergy , atopic dermatitis , ccr4 , egg allergy , food allergy , medicine , antibody , chemokine receptor , inflammation
Atopic dermatitis ( AD ) is a multifactorial T ‐helper ( T h)2‐mediated skin disease frequently associated with elevated serum immunoglobulin ( I g) E and food allergy is also a T h2‐ and I g E ‐mediated adverse immunological reaction. Our previous study indicated the relation of egg allergy history and disease severity of AD . Thus, the purpose of the study was to investigate the levels of I g E specific to major food allergens (egg, milk, wheat) and T h2 chemokines (chemokine [ C‐C motif] ligand [ CCL ]17/thymus and activation regulated chemokine [ TARC ] and CCL 22/macrophage‐derived chemokine [ MDC ]) and the relationship between them. A total of 743 nursery school children were enrolled. Dermatologist‐based physical examination and a questionnaire survey were also conducted. Significantly increased levels of disease severity markers ( CCL 17/ TARC and CCL 22/ MDC ) were confirmed in children with AD . The levels of CCL 22/ MDC in all of the children were markedly high compared with those reported in adults. I g E specific to egg white, ovomucoid, wheat and mite antigen were significantly higher in the AD group than in the non‐ AD group. Among them, I g E specific to egg allergens were well associated with disease severity markers, and I g E specific to ovomucoid seemed particularly well correlated with the presence of egg allergy history. In conclusion, the markedly high level of CCL 22/ MDC in children as compared with those reported in adults may partly explain the AD ‐prone nature of children and their spontaneous remission afterwards. Mild but significant correlation of I g E specific to egg allergens and T h2 chemokines may explain correlation of disease severity and comorbidity of egg allergy in our previous study.