Premium
Three cases of pigmented cosmetic dermatitis‐like eruptions associated with primary Sjögren's syndrome or anti‐ SSA antibody
Author(s) -
Takeo Naoko,
Sakai Takashi,
SaitoShono Tomoko,
Ishikawa Kazushi,
Hatano Yutaka,
Katagiri Kazumoto,
Takahashi Yoshihiro,
Kawano Kenji,
Kimoto Kenichi,
Kubota Toshiaki,
Eshima Nobuoki,
Kojima Hiroto,
Fujiwara Sakuhei
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13300
Subject(s) - medicine , pathology , antigen , immunology , antibody , dermatology
Abstract Pigmented cosmetic dermatitis‐like (Riehl's melanosis‐like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti‐ SSA antibody and possible associations with specific types of human leukocyte antigen ( HLA ) and infiltrating lymphocytes. These middle‐aged Japanese women had reticular facial pigmentation and histopathological examination revealed interface dermatitis, melanophages, and dense lymphocytic infiltration around hair follicles and sweat ducts. HLA typing revealed common antigenic equivalents or genetic typing of HLA ‐A2, DR 52, DPA 1(02:02) and DPB 1(05:01). Immunohistochemical staining revealed major subsets of T cells to be CD 8 and CD 45 RO . Some Foxp3‐ and few IL17‐positive cells were found in strong contrast to the major CD 4 subset of infiltrated T cells in annular erythema associated with Sjögren's syndrome. Apparently, our patients' pigmentation represented a specific etiology associated with primary Sjögren's syndrome or anti‐ SSA antibody.