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Relation between endothelial progenitor cells and arterial stiffness in patients with psoriasis
Author(s) -
Liu JuHua,
Chen Yan,
Zhen Zhe,
Yeung ChiKeung,
Chan Johnny,
Chan Henry H.,
Tse HungFat,
Yiu KaiHang
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13235
Subject(s) - psoriasis , cd34 , medicine , arterial stiffness , pulse wave velocity , progenitor cell , cardiology , immunology , stem cell , blood pressure , biology , genetics
Patients with psoriasis are prone to premature atherosclerosis. We hypothesize that depletion of circulating endothelial progenitor cells ( EPC ) is related to patients with psoriasis and can contribute to the development of atherosclerosis. Thirty‐five plaque‐type psoriasis patients (41.9 ± 5.5 years, 30 men) and 20 age‐ and sex‐matched controls were studied. Four subpopulations of EPC , namely, CD 34 + EPC , CD 133 + EPC , CD 34 + /kinase insert domain‐containing receptor ( KDR ) + EPC and CD 133 + / KDR + EPC were measured by flow cytometry. Arterial stiffness in psoriasis patients was assessed by heart to ankle pulse wave velocity (ha PWV ), augmentation index ( AI ) and carotid intima media thickness ( IMT ). Patients with psoriasis had a lower level of CD 34 + EPC (7.85 ± 2.49% vs 6.26 ± 2.13%, P = 0.02) compared with healthy controls. In patients with psoriasis, level of CD 34 + EPC was negatively related with ha PWV ( r = −0.43 P = 0.01) and Psoriasis Area and Severity Index ( r = −0.39 P = 0.02). Multivariate regression analysis further demonstrated that ha PWV was independently associated with level of CD 34 + EPC . Each percentage decrease in CD 34 + EPC accounted for an increase in ha PWV of +0.02 m/s. The result demonstrated that patients with psoriasis had reduced CD 34 + EPC compared with controls. Importantly, CD 34 + EPC was independently related with ha PWV in these patients. This finding suggests that EPC reduction is associated with the development of arterial stiffness in patients with psoriasis.