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Skin testing of gallic acid‐based hair dye in paraphenylenediamine/paratoluenediamine‐reactive patients
Author(s) -
Choi Yunseok,
Lee Joon Ho,
Kwon Hyok Bu,
An Susun,
Lee AiYoung
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13226
Subject(s) - patch test , hair dyes , gallic acid , dermatology , dyeing , contact allergy , contact dermatitis , allergic contact dermatitis , medicine , ferrous , chemistry , allergy , organic chemistry , immunology , antioxidant
Incidence of allergic contact dermatitis ( ACD ) to para‐phenylenediamine ( PPD )/paratoluenediamine ( PTD ) hair dyes is increasing. Hair dyes utilizing gallic acid ( GA ) may be a safe alternative. However, pretesting is recommended. We investigated the contact sensitivity to ingredients of a dye product; GA , monoethanolamine thioglycolate ( MT ), l ‐cystein and ferrous sulfate, and an appropriate pretest method in 31 patients reactive to PPD and/or PTD . An open test was performed with the test dye following the patch test. Subsequently, a use test was performed twice, with a 4‐week interval. One subject showed a positive reaction to ferrous sulfate in the patch test. Another subject reacted to the first compound alone in the open test. Thirteen subjects manifesting cutaneous lesions from previous regular hair dyeing, showed reactions at the first use of the test dye; and six had reactions with reduced severity at the second test. GA and MT are safe for use in ACD patients reactive to PPD and/or PTD . For predicting contact allergy to hair dyes, the open test appeared to be a better pretest method than the patch test.