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Nutritional, muscular and metabolic characteristics in patients with neurofibromatosis type 1
Author(s) -
Koga Monji,
Yoshida Yuichi,
Imafuku Shinichi
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13218
Subject(s) - medicine , body mass index , lactate dehydrogenase , creatine kinase , endocrinology , creatinine , alanine aminotransferase , neurofibromatosis , anthropometry , creatine , gastroenterology , pathology , biology , enzyme , biochemistry
Abstract Neurofibromatosis type 1 ( NF 1) has many reported clinical characteristics. We previously found that NF 1 patients (especially men) had lower body mass index ( BMI ) than controls, but the reason has not been elucidated. To address this issue, a retrospectively case–control study was conducted. Anthropometric and serum chemistry data that potentially relate to BMI were collected from medical records of NF 1 patients and their age‐ and sex‐matched controls. Enrollment of 98 adult patients who underwent skin surgery with NF 1 (41 men, 57 women) and 173 without NF 1 (74 men, 99 women) were investigated. The median BMI in male NF 1 patients was significantly lower than that of the controls. Triglycerides in male NF 1 patients were significantly lower than male controls, creatine kinase and lactate dehydrogenase in NF 1 patients were also lower than controls, aspartate aminotransferase and alanine aminotransferase showed a lower tendency in NF 1 patients, but were significantly lower in female patients. With correlation analysis, lactate dehydrogenase was moderately correlated with BMI in male NF 1 patients. Creatine kinase and creatinine showed no statistical correlation with BMI in either group. Triglycerides and alanine aminotransferase showed a positive correlation with BMI in both male and female controls, but not in NF 1 patients. In conclusion, only lactate dehydrogenase was moderately correlated with BMI in male NF 1 patients, although results of some nutritional and metabolic parameters suggest a specific metabolism in NF 1.