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Two cases of eosinophilic pustular folliculitis associated with pregnancy
Author(s) -
Matsudate Yoshihiro,
Miyaoka Yuki,
Urano Yoshio
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13179
Subject(s) - medicine , prednisolone , pregnancy , dermatology , dapsone , medical history , topical steroid , surgery , genetics , biology
lated to play an important role in the pathogenesis of PG. A marked persistent leukocytosis (White blood cells, >50 000/lL) with bandemia, when the cause is other than leukemia, defines a leukemoid reaction. The major causes of leukemoid reactions include severe infections, intoxications and malignancies. A previous report showed that severe PG with extensive ulceration may have leukocytosis. That study evaluated 111 PG cases and only two cases presented with a leukemoid reaction. In our case, we speculate that an exacerbation of PG resulted in a leukemoid reaction while an exacerbation of PG by the hyperactivation of neutrophils due to a leukemoid reaction might have been possible, and that the delay of a treatment for the PG induced both a leukemoid reaction and a severe PG. A leukemoid reaction tends to be a sign of poor prognosis in various diseases. In the evaluation of the prognostic impact for PG patients, a statistical rigorous analysis is difficult due to the limited number of cases. Observations of individual cases (including our case) may suggest that a neutrophilic leukemoid reaction is an important sign that a patient is in a progressive course.