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Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3
Author(s) -
Kamiya Koji,
Aoyama Yumi,
Wakashima Chie,
Kudo Tomoko,
Nakajima Kimiko,
Sano Shigetoshi,
Ishii Norito,
Teye Kwesi,
Hashimoto Takashi,
Iwatsuki Keiji,
Tokura Yoshiki
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13086
Subject(s) - desmoglein 3 , desmoglein , pemphigus vulgaris , desmoglein 1 , pemphigus , antibody , immunology , autoantibody , immunoglobulin g , medicine , paraneoplastic pemphigus
In patients with pemphigus vulgaris (PV), pathogenic immunoglobulin (Ig)G antibodies are most commonly directed against desmoglein 3 (Dsg3). It has recently been reported, however, that IgG anti‐desmocollin 3 (Dsc3) antibodies are detected in some cases of pemphigus with or without IgG anti‐Dsg3 antibodies. We present a case of pemphigus with IgG antibodies against Dsg3 and Dsc3. Subsequent studies showed that the cell surface distribution pattern of Dsc3 but not Dsg3 was altered, suggesting that suprabasal acantholytic blisters were induced by IgG anti‐Dsc3 antibodies rather than IgG anti‐Dsg3 antibodies. Our case suggests that anti‐Dsc3 antibodies may be pathogenic in cases positive for the dual cadherin autoantibodies.