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Microbiome and pediatric atopic dermatitis
Author(s) -
Powers Claire E.,
McShane Diana B.,
Gilligan Peter H.,
Burkhart Craig N.,
Morrell Dean S.
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13072
Subject(s) - atopic dermatitis , microbiome , dermatology , immunology , medicine , staphylococcus aureus , pathogenesis , disease , colonization , immune dysregulation , immune system , biology , microbiology and biotechnology , bioinformatics , pathology , bacteria , genetics
Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric health. The pathogenesis of this common disease is not well understood, and the complex role of the skin microbiome in the pathogenesis and progression of atopic dermatitis is being elucidated. Skin commensal organisms promote normal immune system functions and prevent the colonization of pathogens. Alterations in the skin microbiome may lead to increased Staphylococcus aureus colonization and atopic dermatitis progression. Despite the evidence for their important role, probiotics have not been deemed efficacious for the treatment of atopic dermatitis, although studies suggest that probiotics may be effective at preventing the development of atopic dermatitis when given to young infants. This review will cover the most recent published work on the microbiome and pediatric atopic dermatitis.