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Psoriasis‐like lesions in a patient with familial Mediterranean fever
Author(s) -
Ashida Miwa,
Koike Yuta,
Kuwatsuka Sayaka,
Ichinose Kunihiro,
Migita Kiyoshi,
Sano Shigetoshi,
Utani Atsushi
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13068
Subject(s) - familial mediterranean fever , psoriasis , dermis , medicine , infiltration (hvac) , pyrin domain , peripheral blood mononuclear cell , erythema , pathology , immunology , inflammation , dermatology , biology , inflammasome , biochemistry , physics , disease , in vitro , thermodynamics
Familial Mediterranean fever ( FMF ) is a rare hereditary autoinflammatory disorder that is caused by pyrin gene mutation associated with aberrance of the interleukin ( IL )‐1β pathway and characterized by recurrent, self‐limiting attacks of fever and other inflammatory symptoms. We report a case of FMF with annular erythema and psoriasis‐like lesions, the latter of which demonstrated parakeratosis with neutrophil microabscesses and mild inflammatory mononuclear cell infiltration in the upper dermis. Immunofluorescence staining showed IL ‐17‐positive T‐cells. Skin eruption with neutrophil migration in the epidermis may be provoked by T‐helper 17 cell activation through the abnormal IL ‐1β cascade in FMF .