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Age‐related decrease in CD 271 + cells in human skin
Author(s) -
Akamatsu Hirohiko,
Hasegawa Seiji,
Yamada Takaaki,
Mizutani Hiroshi,
Nakata Satoru,
Yagami Akiko,
Matsunaga Kayoko
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13048
Subject(s) - dermis , stem cell , epidermis (zoology) , skin repair , human skin , wound healing , pathology , skin aging , microbiology and biotechnology , biology , medicine , immunology , anatomy , dermatology , genetics
Abstract According to recent studies, stem cells are found in various tissues in our bodies. It has been reported that stem cells can reside in the skin tissues, including the epidermis, dermis, hair follicles and subcutaneous tissues. Homeostasis of the skin is maintained because these stem cells collaborate with each other to form new cells. We previously identified the CD 271(p75 NTR ) + cell as a stem cell that was present in the epidermis, dermis and subcutaneous tissue, and further investigated the role of stem cells in wound healing and their association with skin disease. In this study, we investigated the localization of CD 271 + cells in human skin (epidermis and dermis) and its age‐related changes in stem cells using CD 271 + cells. The study revealed that the number of CD 271 + cells in the epidermis and dermis decreased with aging. It is possible that such an age‐related decrease in stem cells causes impaired regenerative ability and is associated with various skin diseases. If the relationship between stem cells and skin aging and diseases can be elucidated by investigations such as this study, it may lead to the development of novel anti‐aging technologies and medical treatments for skin diseases in the future.