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Downregulated expression of LBH mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
Author(s) -
Chang Yan,
Sheng Yujun,
Cheng Yuyan,
Lin Yan,
Zhu Zhengwei,
Wen Leilei,
Yang Chao,
Yang Lulu,
Liu Lu,
Zhou Fusheng,
Zheng Xiaodong,
Zhang Shengquan,
Cui Yong,
Yang Sen,
Zhang Xuejun
Publication year - 2016
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.13006
Subject(s) - peripheral blood mononuclear cell , pathogenesis , messenger rna , immunology , gene expression , snp , lupus erythematosus , reverse transcription polymerase chain reaction , reverse transcriptase , real time polymerase chain reaction , biology , medicine , gene , polymerase chain reaction , single nucleotide polymorphism , genotype , in vitro , genetics , antibody
We performed a gene expression study to explore whether expression levels of LBH contribute to the pathogenesis of systemic lupus erythematosus ( SLE ) and are associated with the genome‐wide association study‐identified SNP (rs7579944 and rs906868) and the SLE Disease Activity Index ( SLEDAI ). Fluorescent quantitative reverse transcription polymerase chain reaction was used to examine the expression of LBH mRNA in peripheral blood mononuclear cells ( PBMC ) from 62 SLE patients and 69 controls. The expression levels of LBH mRNA in patients with SLE were significantly decreased compared with those in normal controls ( P < 0.001). No significant differences were found between LBH mRNA expression levels and SLEDAI scores, SNP rs7579944 and rs906868. This study suggests that decreased expression of LBH mRNA may be correlated with the pathogenesis of SLE.