Premium
Crater/ulcerated form of infundibular squamous cell carcinoma: A possible distinct entity as a malignant (or high‐grade) counterpart to keratoacanthoma
Author(s) -
Misago Noriyuki,
Inoue Takuya,
Nagase Kotaro,
Tsuruta Noriko,
TaraHashimoto Akiko,
Kimura Hiromi,
Takahara Kanako,
Narita Tomomi,
Narisawa Yutaka
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12871
Subject(s) - keratoacanthoma , pathology , histogenesis , anatomy , impact crater , basal cell , biology , medicine , immunohistochemistry , astrobiology
Follicular squamous cell carcinoma ( SCC ) with infundibular differentiation includes the common and crater forms of infundibular SCC . We previously considered the crater/ulcerated infundibular SCC to be a progressive condition of the common form and histopathologically studied an additional five cases of the crater/ulcerated infundibular SCC , the results of which suggested the following characteristic histopathological features and possible developmental process in this type of SCC : (i) a considerable number of continuous hyperplastic follicular infundibula, which may develop at the beginning of the disease; (ii) hyperplastic infundibula exhibiting an abrupt or gradual transition to the SCC component, which frequently change relative to the neoplastic infundibular canal; and (iii) the presence of multiple sites of branching of the neoplastic infundibular canals and/or complete involvement of large cysts in the neoplastic process over the center of the lesion, resulting in ulceration. Based on these histopathological findings, we considered that crater/ulcerated infundibular SCC involve a considerable number of continuous follicular infundibula from the start, although some cases may develop from the common form. We also emphasize the possible aggressive biological behavior of the crater/ulcerated form. Keratoacanthoma ( KA ) is a unique, benign or borderline malignant neoplasm exhibiting follicular (infundibular/isthmic) differentiation characterized by the involvement of continuous follicular infundibula in multiples. From this standpoint, we consider that crater/ulcerated infundibular SCC is possibly related to KA in terms of histogenesis and is a malignant (or high‐grade) counterpart of KA .