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Rs4948496 within ARID5B gene is associated with clinical features of systemic lupus erythematosus in the C hinese H an population
Author(s) -
Jiang Long,
Wu Jianping,
Li Weiran,
Du Juan,
Wang Wenjun,
Zhu Zhengwei,
Gao Jinping,
Sheng Yujun,
Yin Xianyong,
Zheng Xiaodong,
Li Hui,
Li Yang,
Meng Li,
Fan Xing,
Liu Shengxiu,
Zeng Ming,
Wang Zaixing,
Cui Yong,
Tang Huayang,
Sun Liangdan,
Yang Sen,
Zhang Xuejun
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12841
Subject(s) - single nucleotide polymorphism , odds ratio , snp , genotype , immunology , medicine , gene , population , biology , genetics , environmental health
Abstract In our previous meta‐analysis of genome‐wide association study, we identified the single nucleotide polymorphism ( SNP ) rs4948496 ( P = 5.1 × 10 −11 , odds ratio [ OR ] = 0.85) within the ARID5B gene associated with systemic lupus erythematosus ( SLE ) in a Chinese population. To investigate its association with disease subphenotypes, we further analyzed the genotype data of rs4948496 in 4348 cases and 6679 controls from our previous meta‐analysis and an independent replication cohort in this study. The SNP rs4948496 was significantly associated with SLE ( P = 1.61 × 10 −5 , OR = 0.88, 95% confidence interval [ CI ] = 0.83–0.93) in our group. In case‐only study, the genotype of rs4948496 was associated with antinuclear antibodies ( P = 0.03, OR = 0.81, 95% CI = 0.68–0.98) and anti‐ RNP ( P = 0.03, OR = 0.86, 95% CI = 0.76–0.99). This study showed that rs4948496 in ARID5B is associated with several subphenotypes of SLE and this gene may cause the complicacy of clinical features.