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Prospective study of topical 5‐aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients
Author(s) -
Ma Ying,
Liu Ye,
Wang Qianqian,
Ren Jie,
Xiang Leihong
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12836
Subject(s) - acne , photodynamic therapy , lotion , medicine , dermatology , traditional medicine , chemistry , organic chemistry
Acne vulgaris is one of the most common skin diseases in adolescents. In the present study, we aimed to evaluate the effectiveness and safety of topical 5‐aminolevulinic acid ( ALA )‐mediated photodynamic therapy ( PDT ) for the treatment of severe acne in Chinese adolescent patients. Twenty‐one Chinese adolescent patients aged 12–18 years with Pillsbury III – IV severe facial acne were treated with three courses of ALA ‐ PDT . A 5% ALA lotion was applied topically for 60 min followed by irradiation with light‐emitting diode light at 633 nm with a light intensity of 75–80 mW/cm 2 and a light dose of 90–96 J/cm 2 . Clinical assessment was conducted before and after each treatment, and at each follow‐up session. The total effective rates were 85.71%, 90.48%, and 95.23% after the three PDT sessions, and at the 4‐ and 8‐week follow ups, respectively. ALA ‐ PDT is an effective treatment for severe adolescent acne vulgaris, and is associated with mild and reversible side‐effects.