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Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis
Author(s) -
Miura Shunsuke,
Asano Yoshihide,
Saigusa Ryosuke,
Yamashita Takashi,
Taniguchi Takashi,
Takahashi Takehiro,
Ichimura Yohei,
Toyama Tetsuo,
Tamaki Zenshiro,
Tada Yayoi,
Sugaya Makoto,
Sato Shinichi,
Kadono Takafumi
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12824
Subject(s) - medicine , multiple sclerosis , systemic circulation , cardiology , immunology
Adipokines have been shown to be potentially involved in various pathological processes of systemic sclerosis ( SS c), including inflammation, vasculopathy and fibrosis, through their pleiotropic effects. Omentin is a member of the adipokines, and has a protective effect against vascular inflammation and pathological remodeling leading to atherosclerosis as well as a vasodilatory effect. To assess the potential role of omentin in the development of SS c, we determined serum omentin levels by enzyme‐linked immunosorbent assay in 66 SS c and 21 control subjects and evaluated their clinical correlation. Serum omentin levels were significantly decreased in diffuse cutaneous SS c patients compared with limited cutaneous SS c patients, while comparable between total SS c patients and healthy controls. In diffuse cutaneous (dc) SS c, patients with a disease duration of 5 years or less had serum omentin levels significantly lower than those with a disease duration of more than 5 years. In total SS c, serum omentin levels were significantly higher in patients with elevated right ventricular systolic pressure than in the others, while serum omentin levels did not correlate with fibrotic and systemic inflammatory parameters. These results suggest that a loss of omentin‐dependent protection against vascular inflammation and remodeling may be related to pathological vascular events of early dc SS c. The elevation of serum omentin levels may serve as a marker of vascular involvement leading to pulmonary arterial hypertension in SS c, which is possibly due to the compensatory induction of omentin against the increased pulmonary vascular tone.