Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis | Zendy

Miura Shunsuke | Zendy; Asano Yoshihide | Zendy; Saigusa Ryosuke | Zendy; Yamashita Takashi | Zendy; Taniguchi Takashi | Zendy; Takahashi Takehiro | Zendy; Ichimura Yohei | Zendy; Toyama Tetsuo | Zendy; Tamaki Zenshiro | Zendy; Tada Yayoi | Zendy; Sugaya Makoto | Zendy; Sato Shinichi | Zendy; Kadono Takafumi | Zendy

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Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis

Author(s) -

Miura Shunsuke,

Asano Yoshihide,

Saigusa Ryosuke,

Yamashita Takashi,

Taniguchi Takashi,

Takahashi Takehiro,

Ichimura Yohei,

Toyama Tetsuo,

Tamaki Zenshiro,

Tada Yayoi,

Sugaya Makoto,

Sato Shinichi,

Kadono Takafumi

Publication year - 2015

Publication title -

the journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.9

H-Index - 65

eISSN - 1346-8138

pISSN - 0385-2407

DOI - 10.1111/1346-8138.12810

Subject(s) - adipokine , medicine , multiple sclerosis , correlation , systemic inflammation , inflammation , endocrinology , gastroenterology , immunology , leptin , obesity , geometry , mathematics

Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis ( SS c). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10 ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SS c and control subjects, serum vaspin levels were significantly decreased in SS c patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.

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