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Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis
Author(s) -
Miura Shunsuke,
Asano Yoshihide,
Saigusa Ryosuke,
Yamashita Takashi,
Taniguchi Takashi,
Takahashi Takehiro,
Ichimura Yohei,
Toyama Tetsuo,
Tamaki Zenshiro,
Tada Yayoi,
Sugaya Makoto,
Sato Shinichi,
Kadono Takafumi
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12810
Subject(s) - adipokine , medicine , multiple sclerosis , correlation , systemic inflammation , inflammation , endocrinology , gastroenterology , immunology , leptin , obesity , geometry , mathematics
Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis ( SS c). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10 ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SS c and control subjects, serum vaspin levels were significantly decreased in SS c patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.