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Pemphigoid with antibodies to laminin γ1, BP 180 and BP 230, associated with psoriasis vulgaris: Successful disease control with cyclosporin
Author(s) -
Imanishi Akiko,
Tateishi Chiharu,
Imanishi Hisayoshi,
SowaOsako Junko,
Koga Hiroshi,
Tsuruta Daisuke,
Hashimoto Takashi
Publication year - 2015
Publication title -
the journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 65
eISSN - 1346-8138
pISSN - 0385-2407
DOI - 10.1111/1346-8138.12798
Subject(s) - bullous pemphigoid , autoantibody , psoriasis , pemphigoid , cicatricial pemphigoid , antibody , medicine , erythema , histopathology , pemphigus vulgaris , laminin , pathology , dermatology , immunology , autoimmune disease , chemistry , biochemistry , cell
Both anti‐laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200‐kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP 180 and BP 230, both of which are hemidesmosomal proteins. We experienced a 69‐year‐old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters. Patient immunoglobulin G antibodies labeled both the epidermal and dermal sides of 1 mol/L NaCl‐split human skin by indirect immunofluorescent microscopy and recognized laminin γ1, BP 180 and BP 230 by immunoblotting. To the best of our knowledge, this is the first report of coexistence of psoriasis and atypical pemphigoid with these three autoantibodies.